Kratom, Opioid, and Testosterone

Kratom, Opioid, and Testosterone – The Happy Herb’s Effects on Testosterone

In Food and Supplements, Review by Marcel4 Comments

Kratom aka mitragyna speciosa is a new underground opioid herb that’s known for it’s calming effects, deceased anxiety, mood enhancement, communication skills enhancement, and other good things. That sounds good but there’s a big flaw in this herb.

Kratom aka Mitragyna Speciosa, Opioid, and Testosterone

The herb kratom aka mitragyna speciosa is classified as an opioid. Opioids are substances that act on opioid receptors to produce morphine-like effects. And opioids have an effect on testosterone and androgen receptors as well.

This study found that the use of opioids as a long-term treatment for chronic pain has increased dramatically. Accompanying this upsurge in the use of long-term opioid therapy has been an increase in the occurrence of opioid associated endocrinopathy, most commonly manifested as an androgen deficiency and therefore referred to as opioid associated androgen deficiency.

This syndrome is characterized by the presence of inappropriately low levels of gonadotropins (follicle stimulating hormone and luteinizing hormone) leading to inadequate production of sex hormones, particularly testosterone.

The conclusion from this study is that androgen deficiency is induced by opioid.

Then this study found some interesting things, concluding that opioid suppresses testosterone.

  1. Testosterone is suppressed by nearly 50% in opioid-using men.
  2. This suppression is not specific to methadone but to all opioids in general, whether it be for illicit or therapeutic use.
  3. Testosterone was not found to be suppressed in studies examining opioid-using women.

This study found that men taking long-acting chronic pain meds, such as opioids, are 5 times more likely to have low testosterone levels.

This study concluded the same thing – participants on opioids had higher odds of having low testosterone levels than those unexposed.

This study concluded – testosterone level is suppressed in men with regular opioid use regardless of opioid type.

This study found and concluded – patients on higher opioid therapy had increased cortisol levels, and male patients had lower testosterone levels. The study suggests that opioid therapy in patients with advanced cancer may inhibit gonadal function while sparing the adrenal axis.

This study says the presence of morphine in the culture medium strongly decreased testosterone.

This study found that hypogonadism was due to long-term opioid use.

This study concluded – morphine and kisspeptin/GPR54 signaling pathway may interact with each other to control the hypothalamic-pituitary-gonadal axis.

This study found – methadone induces testosterone suppression in patients with opioid addiction.

Opiod, kratom, and mitragyna speciosa

Conclusion on Kratom aka Mitragyna Speciosa, Opioid, and Testosterone

Opioids lower testosterone big time, proven by a lot of studies. Methadone suppresses testosterone. Then we’ve got kratom, which is an opioid, so it most likely lowers testosterone like any other opioid. I see people building businesses around kratom and how great it is. It ain’t so great though. Do your research before you blindly hop on a plant or herb.

Instead of suppressing your testosterone with kratom, get yourself some natural herbs and supplements that actually work at increasing testosterone.


  1. Bobby J

    Very flawed study to make Kratom look like the bad guy.. One problem .. Kratom is not an opoid! It is a very useful and beneficial. Do some research.

    1. Alexander

      I used kratom for 5 years and now that I’ve quit, which was very difficult, my testosterone levels are now very low. I had them checked with a blood test. After quitting I quickly lost my libido, my motivation to do most things, and I gained a lot of weight. I was using 20 to 30 grams a day by the end of my addiction. Kratom should only be used short term, in my opinion.

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